PUBLICATIONS
2023
Liao Y, Sloan DC, Widjaja JH, . KCTD5 Forms Hetero-Oligomeric Complexes with Various Members of the KCTD Protein Family. Int J Mol Sci. 2023 Sep 20;24(18):14317. doi: 10.3390/ijms241814317. PubMed PMID: 37762619; PubMed Central PMCID: PMC10531988.
Widjaja JH, Sloan DC, Hauger JA, . Customizable Open-Source Rotating Rod (Rotarod) Enables Robust Low-Cost Assessment of Motor Performance in Mice. eNeuro. 2023 Sep 6;10(9):ENEURO.0123-23.2023. doi: 10.1523/ENEURO.0123-23.2023. PubMed PMID: 37673671; PubMed Central PMCID: PMC10484359.
Sloan DC, Cryan CE, Multiple potassium channel tetramerization domain (KCTD) family members interact with Gβγ, with effects on cAMP signaling. J Biol Chem. 2023 Mar;299(3):102924. doi: 10.1016/j.jbc.2023.102924. Epub 2023 Feb 1. PubMed PMID: 36736897; PubMed Central PMCID: PMC9976452.
2022
Wijayasinghe YS, Bhansali MP, Borkar MR, Chaturbhuj GU, , Viola RE, Bhansali PR. A Comprehensive Biological and Synthetic Perspective on 2-Deoxy-d-Glucose (2-DG), A Sweet Molecule with Therapeutic and Diagnostic Potentials. J Med Chem. 2022 Mar 10;65(5):3706-3728. doi: 10.1021/acs.jmedchem.1c01737. Epub 2022 Feb 22. PubMed PMID: 35192360.
Wang D, Dao M, , Giles AC, Martemyanov KA, Grill B. Genetic modeling of GNAO1 disorder delineates mechanisms of Gαo dysfunction. Hum Mol Genet. 2022 Feb 21;31(4):510-522. doi: 10.1093/hmg/ddab235. PubMed PMID: 34508586; PubMed Central PMCID: PMC8863422.
, Marwari S, Li X, Sloan DC, Young BD, Wohlschlegel JA, Martemyanov KA. Members of the KCTD family are major regulators of cAMP signaling. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1). doi: 10.1073/pnas.2119237119. PubMed PMID: 34934014; PubMed Central PMCID: PMC8740737.
2021
Amirrad F, Pala R, Shamloo K, , Nauli SM. Arrhythmogenic Hearts in PKD2 Mutant Mice Are Characterized by Cardiac Fibrosis, Systolic, and Diastolic Dysfunctions. Front Cardiovasc Med. 2021;8:772961. doi: 10.3389/fcvm.2021.772961. eCollection 2021. PubMed PMID: 34901233; PubMed Central PMCID: PMC8661014.
Stoveken HM, Fernandez-Vega V, , Patil DN, Shumate J, Bannister TD, Scampavia L, Spicer TP, Martemyanov KA. Identification of Potential Modulators of the RGS7/Gβ5/R7BP Complex. SLAS Discov. 2021 Oct;26(9):1177-1188. doi: 10.1177/24725552211020679. Epub 2021 Jun 11. PubMed PMID: 34112017; PubMed Central PMCID: PMC8552049.
Melis C, Beauvais G, , Cirnaru MD, Otrimski G, Creus-Muncunill J, Martemyanov KA, Gonzalez-Alegre P, Ehrlich ME. Striatal Dopamine Induced ERK Phosphorylation Is Altered in Mouse Models of Monogenic Dystonia. Mov Disord. 2021 May;36(5):1147-1157. doi: 10.1002/mds.28476. Epub 2021 Jan 17. PubMed PMID: 33458877; NIHMSID:NIHMS1827658.
Masuho I, Skamangas NK, , Martemyanov KA. Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling. Cell Syst. 2021 Apr 21;12(4):324-337.e5. doi: 10.1016/j.cels.2021.02.001. Epub 2021 Mar 4. PubMed PMID: 33667409; PubMed Central PMCID: PMC8068604.
, Masuho I, Dao M, Sutton LP, Zucca S, Iwamoto H, Patil DN, Wang D, Birnbaumer L, Blakely RD, Grill B, Martemyanov KA. Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders. Cell Rep. 2021 Feb 2;34(5):108718. doi: 10.1016/j.celrep.2021.108718. PubMed PMID: 33535037; PubMed Central PMCID: PMC7903328.
2020
Masuho I, Balaji S, , Skamangas NK, Chavali S, Tesmer JJG, Babu MM, Martemyanov KA. A Global Map of G Protein Signaling Regulation by RGS Proteins. Cell. 2020 Oct 15;183(2):503-521.e19. doi: 10.1016/j.cell.2020.08.052. Epub 2020 Oct 1. PubMed PMID: 33007266; PubMed Central PMCID: PMC7572916.
. Dorsal Striatum Dynamically Incorporates Velocity Adjustments during Locomotion. J Neurosci. 2020 Sep 2;40(36):6822-6824. doi: 10.1523/JNEUROSCI.0905-20.2020. PubMed PMID: 32878975; PubMed Central PMCID: PMC7470919.
2019
Doyle TB, , Ejendal KF, Hayes MP, Soto-Velasquez M, Martemyanov KA, Dessauer CW, Hu CD, Watts VJ. Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D1 and D2 Medium Spiny Neurons using Bimolecular Fluorescence Complementation Screening. Cells. 2019 Nov 19;8(11). doi: 10.3390/cells8111468. PubMed PMID: 31752385; PubMed Central PMCID: PMC6912275.
, Dao MT, Martemyanov KA. Allostatic Changes in the cAMP System Drive Opioid-Induced Adaptation in Striatal Dopamine Signaling. Cell Rep. 2019 Oct 22;29(4):946-960.e2. doi: 10.1016/j.celrep.2019.09.034. PubMed PMID: 31644915; PubMed Central PMCID: PMC6871051.
Green MV, Pengo T, Raybuck JD, Naqvi T, McMullan HM, Hawkinson JE, Marron Fernandez de Velasco E, , Martemyanov KA, Satterfield R, Young SM Jr, Thayer SA. Automated Live-Cell Imaging of Synapses in Rat and Human Neuronal Cultures. Front Cell Neurosci. 2019;13:467. doi: 10.3389/fncel.2019.00467. eCollection 2019. PubMed PMID: 31680875; PubMed Central PMCID: PMC6811609.
Cirnaru MD, Melis C, Fanutza T, Naphade S, Tshilenge KT, , Martemyanov KA, Plotkin JL, Ellerby LM, Ehrlich ME. Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D1 Receptor Signaling. eNeuro. 2019 Sep/Oct;6(5). doi: 10.1523/ENEURO.0305-19.2019. Print 2019 Sep/Oct. PubMed PMID: 31541002; PubMed Central PMCID: PMC6787343.
Sutton LP, , Ostrovskaya O, Zucca S, Dao M, Orlandi C, Song C, Xie K, Martemyanov KA. NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control. PLoS Biol. 2019 Oct;17(10):e3000477. doi: 10.1371/journal.pbio.3000477. eCollection 2019 Oct. PubMed PMID: 31600280; PubMed Central PMCID: PMC6805008.
2018
Orlandi C, Sutton LP, , Song C, Martemyanov KA. Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors. Neuropsychopharmacology. 2019 Feb;44(3):642-653. doi: 10.1038/s41386-018-0238-y. Epub 2018 Oct 11. PubMed PMID: 30546127; PubMed Central PMCID: PMC6333837.
Masuho I, Chavali S, , Skamangas NK, Simonyan K, Patil DN, Kramer GM, Ozelius L, Babu MM, Martemyanov KA. Molecular Deconvolution Platform to Establish Disease Mechanisms by Surveying GPCR Signaling. Cell Rep. 2018 Jul 17;24(3):557-568.e5. doi: 10.1016/j.celrep.2018.06.080. PubMed PMID: 30021154; PubMed Central PMCID: PMC6077248.
, Patil DN, Madoux F, Fossetta J, Scampavia L, Spicer TP, Martemyanov KA. A High-Throughput Time-Resolved Fluorescence Energy Transfer Assay to Screen for Modulators of RGS7/Gβ5/R7BP Complex. Assay Drug Dev Technol. 2018 Apr;16(3):150-161. doi: 10.1089/adt.2017.839. PubMed PMID: 29658790; PubMed Central PMCID: PMC5906730.
Sutton LP, Orlandi C, Song C, Oh WC, , Xie K, Filippini A, Xie X, Satterfield R, Yaeger JDW, Renner KJ, Young SM Jr, Xu B, Kwon H, Martemyanov KA. Orphan receptor GPR158 controls stress-induced depression. Elife. 2018 Feb 8;7. doi: 10.7554/eLife.33273. PubMed PMID: 29419376; PubMed Central PMCID: PMC5823542.
, Zucca S, MacMullen CM, Dao MT, Johnston C, Iwamoto H, Blakely RD, Davis RL, Martemyanov KA. Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits. Cell Rep. 2018 Jan 2;22(1):255-268. doi: 10.1016/j.celrep.2017.12.022. PubMed PMID: 29298426; PubMed Central PMCID: PMC5761078.
2016
Xie K, Colgan LA, Dao MT, , Sutton LP, Orlandi C, Boye SL, Boye SE, Shih CC, Li Y, Xu B, Smith RG, Yasuda R, Martemyanov KA. NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum. Curr Biol. 2016 Nov 21;26(22):2992-3003. doi: 10.1016/j.cub.2016.09.010. Epub 2016 Oct 20. PubMed PMID: 27773571; PubMed Central PMCID: PMC5121064.
, Martemyanov KA. Association with the Plasma Membrane Is Sufficient for Potentiating Catalytic Activity of Regulators of G Protein Signaling (RGS) Proteins of the R7 Subfamily. J Biol Chem. 2016 Mar 25;291(13):7195-204. doi: 10.1074/jbc.M115.713446. Epub 2016 Jan 25. PubMed PMID: 26811338; PubMed Central PMCID: PMC4807299.
2015
Atkinson KF, Kathem SH, Jin X, , Abou-Alaiwi WA, Nauli AM, Nauli SM. Dopaminergic signaling within the primary cilia in the renovascular system. Front Physiol. 2015;6:103. doi: 10.3389/fphys.2015.00103. eCollection 2015. Review. PubMed PMID: 25932013; PubMed Central PMCID: PMC4399208.
2014
, Jin X, Williams FE, Nauli SM. Primary cilium regulates CaV1.2 expression through Wnt signaling. J Cell Physiol. 2014 Dec;229(12):1926-34. doi: 10.1002/jcp.24642. PubMed PMID: 24700505.
Jin X, , Aal-Aaboda MS, Duan Q, Zhou J, Nauli SM. L-type calcium channel modulates cystic kidney phenotype. Biochim Biophys Acta. 2014 Sep;1842(9):1518-26. doi: 10.1016/j.bbadis.2014.06.001. Epub 2014 Jun 9. PubMed PMID: 24925129; PubMed Central PMCID: PMC4125496.
Jin X, Mohieldin AM, , Green JA, Shah JV, Mykytyn K, Nauli SM. Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli. Cell Mol Life Sci. 2014 Jun;71(11):2165-78. doi: 10.1007/s00018-013-1483-1. Epub 2013 Oct 9. PubMed PMID: 24104765; PubMed Central PMCID: PMC3981964.
Upadhyay VS, , Kathem SH, Hwang JJ, Aboualaiwi WA, Nauli SM. Roles of dopamine receptor on chemosensory and mechanosensory primary cilia in renal epithelial cells. Front Physiol. 2014;5:72. doi: 10.3389/fphys.2014.00072. eCollection 2014. PubMed PMID: 24616705; PubMed Central PMCID: PMC3935400.
Aboualaiwi WA, , Ratnam S, Joe B, Liu L, Booth RL, Rodriguez I, Herbert BS, Bacallao RL, Fruttiger M, Mak TW, Zhou J, Nauli SM. Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation. Circulation. 2014 Feb 11;129(6):660-72. doi: 10.1161/CIRCULATIONAHA.113.005746. Epub 2013 Nov 14. PubMed PMID: 24235270; PubMed Central PMCID: PMC3946000.
2012
, Jin X, Nauli SM. Primary cilia are mechanosensory organelles with chemosensory roles. In: Kamkin A, Kiseleva I, editors. Mechanical Stretch and Cytokines Dordrecht: Springer Netherlands; 2012. Chapter 9; p.201-222.
2011
Wendland TR, , Kaur J, Mukherjee J, Chen J, Tan X, Kirchhoff JR, Tillekeratne VL. In Situ Self Assembly of Thiolated ortho-Quinone Capped Electrocatalysts for Bioanalytical Applications. Electroanalysis. 2011 October; 23(10):2275–2279. doi: 10.1002/elan.201100276.
2010
, Horvat CM, Behler JH, Aboualaiwi WA, Nauli AM, Williams FE, Nauli SM. A Comparative Study of Embedded and Anesthetized Zebrafish in vivo on Myocardiac Calcium Oscillation and Heart Muscle Contraction. Front Pharmacol. 2010;1:139. doi: 10.3389/fphar.2010.00139. eCollection 2010. PubMed PMID: 21833178; PubMed Central PMCID: PMC3153013.